About the Study
- Very few children in both groups had a fever of 103.1 degrees or higher. There was no significant difference between the two groups.
After the initial vaccination :
- 42% of infants in the treatment group had fever greater than 100.4 degrees, compared to 66% of infants in the control group.
- Antibody concentration was significantly lower in the treatment group compared to the control group.
After the booster vaccination:
- 36% of infants in the treatment group had fever greater than 100.4 degrees, compared to 58% of infants in the control group.
- Antibody concentration was still significantly lower in the treatment group than in the control group for certain antibodies (eg, tetanus, pneumococcal).
How Does This Affect You?
American Academy of Family Physicians http://familydoctor.org/
American Academy of Pediatrics http://www.aap.org/
Prymula R, Siegrist CA, Chilbek R, et al. Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open- label, randomised controlled trials. The Lancet . 2009 Oct;374(9698):1339-1350.
- Reviewer: Brian Randall, MD